Diagnostic Parameters Amyotrophic Lateral Sclerosis

The diagnosis of Amyotrophic Lateral Sclerosis [ALS] requires:

A - the presence of:

(A:1) evidence of lower motor neuron (LMN) degeneration
by clinical, electrophysiological or neuropathologic examination,

(A:2) evidence of upper motor neuron (UMN) degeneration
by clinical examination, and

(A:3) progressive spread of symptoms or signs within a region or to other regions,
as determined by history or examination,

together with

B - the absence of:

(B:1) electrophysiological and pathological evidence of other disease
processes that might explain the signs of LMN and/or UMN degeneration, and

(B:2) neuroimaging evidence of other disease processes that might explain the
observed clinical and electrophysiological signs.Diagnostic